Maternal obesity enhances oocyte chromosome abnormalities associated with aging
نویسندگان
چکیده
منابع مشابه
Structural Chromosome Abnormalities Associated with Obesity: Report of Four New subjects and Review of Literature
Obesity in humans is a complex polygenic trait with high inter-individual heritability estimated at 40-70%. Candidate gene, DNA linkage and genome-wide association studies (GWAS) have allowed for the identification of a large set of genes and genomic regions associated with obesity. Structural chromosome abnormalities usually result in congenital anomalies, growth retardation and developmental ...
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Cytogenetic studies were performed on direct and 24-hour culture preparations of eight lymph node biopsies from seven patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)-associated lymphadenopathy in whom histological evidence of lymphoma was not detected. Three of these seven had chromosomal abnormalities, including chromosome instability in one and clonal chr...
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239 sulted in 2 normal living children. The 3rd pregnancy resulted in a spontaneous abortion. Her last pregnancy at the age of 29 years resulted in a child with Down's syndrome. The child had 47 chromosomes with trisomy 21. The patient also has 47 chromosomes with a triple X karyotype. About 200% of her buccal cells contain 2 chromatin bodies. The patient's husband is physically and mentally no...
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BACKGROUND This study explored the association between maternal obesity during pregnancy and the inflammatory markers, tumor necrosis factor-α, interleukin-6 and high sensitivity C-reactive protein (hs-CRP), and the cytokine, adiponectin, in the offspring. METHODS Weight, height, Tanner stage and biomarkers were measured in thirty-four 12-year-old children, from the Infant Growth Study, who w...
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Maternal obesity has a major impact on pregnancy outcomes. There is growing evidence that maternal obesity has a negative influence on placental development and function, thereby adversely influencing offspring programming and health outcomes. However, the molecular mechanisms underlying these processes are poorly understood. We analysed ten term placenta's whole transcriptomes in obese (n = 5)...
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ژورنال
عنوان ژورنال: Chromosoma
سال: 2019
ISSN: 0009-5915,1432-0886
DOI: 10.1007/s00412-019-00716-6